Pub. Date : 2019 May
PMID : 31086816
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability. | Platinum | snail family transcriptional repressor 1 | Homo sapiens |
| 2 | Here, we report that the ubiquitin-specific protease 1 (USP1) mediates ovarian cancer cell resistance to platinum, by regulating the stability of Snail, which, in turn, promotes tumor dissemination. | Platinum | snail family transcriptional repressor 1 | Homo sapiens |
| 3 | At the molecular level, we observed that upon platinum treatment, USP1 is phosphorylated by ATM and ATR and binds to Snail. | Platinum | snail family transcriptional repressor 1 | Homo sapiens |