Pub. Date : 2019 May 10
PMID : 31083300
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice. | Methylcholanthrene | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 2 | 3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice. | Methylcholanthrene | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 3 | In this study, we treated male Tiparp-/- or wild type (WT) mice with a single injection of 100 mg/kg 3-methylcholanthrene (3MC). | Methylcholanthrene | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 4 | Consistent with TIPARP"s role as a repressor of AHR signaling, 3MC-treated Tiparp-/- mice exhibited increased hepatic Cyp1a1 and Cyp1b1 levels compared with WT mice. | Methylcholanthrene | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 5 | Consistent with TIPARP"s role as a repressor of AHR signaling, 3MC-treated Tiparp-/- mice exhibited increased hepatic Cyp1a1 and Cyp1b1 levels compared with WT mice. | Methylcholanthrene | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |
| 6 | Our study reveals that Tiparp-/- mice have increased sensitivity to 3MC-induced liver toxicity, but unlike with TCDD, lethality is due to chylous ascites rather than wasting syndrome. | Methylcholanthrene | TCDD-inducible poly(ADP-ribose) polymerase | Mus musculus |