Title : Creation of a test plasmid for detecting G-C-to-T-A transversions by changing serine to arginine in the active site of beta-lactamase.

Pub. Date : 1987 Jun

PMID : 3108235






1 Functional Relationships(s)
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1 We characterized the reversion of the mutant bla gene by a number of mutagens and in different genetic backgrounds and demonstrated that full ampicillin resistance can be restored only by a G-C-to-T-A transversion occurring at the first base of the codon. Ampicillin beta-lactamase Escherichia coli