Pub. Date : 2019
PMID : 31080408
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking. | Diazepam | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 2 | In contrast, both gamma2 and the postsynaptic scaffolding protein gephyrin showed diminished total protein levels following a single DZP treatment in vitro and in mouse cortical tissue. | Diazepam | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 3 | Selective immunoprecipitation of gamma2 from cultured neurons revealed enhanced ubiquitination of this subunit following DZP exposure. | Diazepam | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 4 | Moreover, we found DZP simultaneously enhanced synaptic exchange of both gamma2-GABAARs and gephyrin using fluorescence recovery after photobleaching (FRAP) techniques. | Diazepam | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 5 | Finally we provide the first proteomic analysis of the BZD sensitive GABAAR interactome in DZP vs. vehicle treated mice. | Diazepam | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |
| 6 | Collectively, our results indicate DZP exposure elicits down-regulation of gephyrin scaffolding and BZD sensitive GABAAR synaptic availability via multiple dynamic trafficking processes. | Diazepam | gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 | Mus musculus |