Title : Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) dual activator tool compound: Multi-dimensional optimization of BL-1249.

Pub. Date : 2019 Jul 1

PMID : 31072652






1 Functional Relationships(s)
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1 This letter describes a focused, multi-dimensional optimization campaign around BL-1249, a fenamate class non-steroidal anti-inflammatory and a known activator of the K2P potassium channels TREK-1 (K2P2.1) and TREK-2 (K2P10.1). Fenamates potassium two pore domain channel subfamily K member 2 Homo sapiens