Title : Volatile anesthetics affect macrophage phagocytosis.

Pub. Date : 2019

PMID : 31071106






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Photolabeling experiments showed that sevoflurane directly bound to Rap1. Sevoflurane RAS-related protein 1a Mus musculus
2 Mutagenesis analysis demonstrated that the sevoflurane binding site affected Rap1 activation and macrophage phagocytosis. Sevoflurane RAS-related protein 1a Mus musculus
3 Our study showed for the first time that sevoflurane served as a novel small GTPase Rap1 inhibitor. Sevoflurane RAS-related protein 1a Mus musculus
4 The sevoflurane binding site was located outside the known Rap1 functional sites, indicating the discovery of a new functional site on Rap1 and this site would serve as a pocket for the development of novel Rap1 inhibitors. Sevoflurane RAS-related protein 1a Mus musculus
5 The sevoflurane binding site was located outside the known Rap1 functional sites, indicating the discovery of a new functional site on Rap1 and this site would serve as a pocket for the development of novel Rap1 inhibitors. Sevoflurane RAS-related protein 1a Mus musculus
6 The sevoflurane binding site was located outside the known Rap1 functional sites, indicating the discovery of a new functional site on Rap1 and this site would serve as a pocket for the development of novel Rap1 inhibitors. Sevoflurane RAS-related protein 1a Mus musculus