Title : Hydrogen-Bonding-Assisted Exogenous Nucleophilic Reagent Effect for β-Selective Glycosylation of Rare 3-Amino Sugars.

Pub. Date : 2019 May 29

PMID : 31067044






1 Functional Relationships(s)
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1 Current protocol leverages a C-3 axial sulfonamide group in 3,5- trans-3-ADSs as a hydrogen-bond (H-bond) donor and repurposes substoichiometric phosphine oxide as an exogenous nucleophilic reagent (exNu) to establish an intramolecular H-bond between the former and the derived alpha-oxyphosphonium ion. Sulfonamides adenylosuccinate synthase 2 Homo sapiens