Pub. Date : 2019 Aug
PMID : 31066116
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |
| 2 | And under cellular stress, the reactive oxygen species (ROS) levels decreased in MARVELD1 expressed cells while increased in the cells of MARVELD1-specific siRNA treatment. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |
| 3 | And under cellular stress, the reactive oxygen species (ROS) levels decreased in MARVELD1 expressed cells while increased in the cells of MARVELD1-specific siRNA treatment. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |
| 4 | And under cellular stress, the reactive oxygen species (ROS) levels decreased in MARVELD1 expressed cells while increased in the cells of MARVELD1-specific siRNA treatment. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |
| 5 | And under cellular stress, the reactive oxygen species (ROS) levels decreased in MARVELD1 expressed cells while increased in the cells of MARVELD1-specific siRNA treatment. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |
| 6 | Meanwhile, MARVELD1 overexpression significantly promoted the inhibition of tumor cell proliferation under cellular stress via affecting ROS metabolism, not cell cycle. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |
| 7 | In xenograft tumor tissues with MARVELD1 expression, the tumor growth was inhibited and accompanied by the lower ROS levels. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |
| 8 | And the enhanced sensitivity to chemotherapeutic drugs clearly depended on the ability of MARVELD1 scavenge the ROS in carcinoma cells of the reproductive system. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |
| 9 | Our findings clearly explain that MARVELD1 may regulate tumor cell proliferation and sensitivity to chemotherapeutic drugs via reducing the exorbitant ROS. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |
| 10 | The mechanism was that MARVELD1 interacted with CAT to maintain latter stability, and then ensure continuous ROS scavenge. | Reactive Oxygen Species | MARVEL domain containing 1 | Homo sapiens |