Pub. Date : 2019 Jun 19
PMID : 31034197
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo. | Pyrazines | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 2 | Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo. | Pyrazines | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 3 | In subsequent whole-cell patch clamp recordings, the two most effective compounds (pyrazine-fused triterpenoids 8 and 9) displayed a reversible and dose- and voltage-dependent effect to block the TRPA1 ion channel at submicromolar concentrations. | Pyrazines | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 4 | The results introduce betulin-derived pyrazine-fused triterpenoids as promising novel antagonists of TRPA1 that are potentially useful in treating diseases with a TRPA1-mediated adverse component. | Pyrazines | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |
| 5 | The results introduce betulin-derived pyrazine-fused triterpenoids as promising novel antagonists of TRPA1 that are potentially useful in treating diseases with a TRPA1-mediated adverse component. | Pyrazines | transient receptor potential cation channel, subfamily A, member 1 | Mus musculus |