Pub. Date : 2019 Jul
PMID : 31028998
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibits the proliferation of rheumatoid arthritis fibroblast-like synoviocytes through IGF-IR/PI3K/AKT/m-TOR pathway. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | More importantly, metformin induced G2/M cell cycle phase arrest in RA-FLS via the IGF-IR/PI3K/AKT/ m-TOR pathway and inhibited m-TOR phosphorylation through both the IGF-IR/PI3K/AKT signaling pathways thereby further upregulating and down-regulating p70s6k and 4E-BP1 phosphorylation, respectively; however, metformin was found not to induce apoptosis in RA-FLSs. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | More importantly, metformin induced G2/M cell cycle phase arrest in RA-FLS via the IGF-IR/PI3K/AKT/ m-TOR pathway and inhibited m-TOR phosphorylation through both the IGF-IR/PI3K/AKT signaling pathways thereby further upregulating and down-regulating p70s6k and 4E-BP1 phosphorylation, respectively; however, metformin was found not to induce apoptosis in RA-FLSs. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Moreover, IGF-IR/PI3K/AKT m-TOR signaling pathway can be regulated by metformin. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |