Pub. Date : 2019 Aug
PMID : 31028570
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhancement of chemosensitivity in 5-fluorouracil-resistant colon cancer cells with carcinoembryonic antigen-specific RNA aptamer. | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |
| 2 | However, a major issue of 5-FU therapy is the occurrence of chemoresistance, and the fact that 5-FU induces CEA overexpression, which may induce the 5-FU resistance. | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |
| 3 | However, a major issue of 5-FU therapy is the occurrence of chemoresistance, and the fact that 5-FU induces CEA overexpression, which may induce the 5-FU resistance. | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |
| 4 | In the present study, we tested whether protecting CEA using the CEA aptamer could enhance 5-FU sensitivity in chemoresistant LS174T colon cancer cells. | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |
| 5 | In the present study, we tested whether protecting CEA using the CEA aptamer could enhance 5-FU sensitivity in chemoresistant LS174T colon cancer cells. | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |
| 6 | We observed that the CEA aptamer sensitized the 5-FU-resistant colon cancer cell line to 5-FU more than five-fold (IC50 ~ 5.995 muM), compared with cells treated with 5-FU alone (IC50 ~ 31.46 muM). | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |
| 7 | We observed that the CEA aptamer sensitized the 5-FU-resistant colon cancer cell line to 5-FU more than five-fold (IC50 ~ 5.995 muM), compared with cells treated with 5-FU alone (IC50 ~ 31.46 muM). | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |
| 8 | We observed that the CEA aptamer sensitized the 5-FU-resistant colon cancer cell line to 5-FU more than five-fold (IC50 ~ 5.995 muM), compared with cells treated with 5-FU alone (IC50 ~ 31.46 muM). | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |
| 9 | In conclusion, CEA-specific aptamer improved 5-FU sensitivity in chemoresistant colon cancer cells in vitro and in vivo, and thus represents a novel 5-FU adjuvant to overcome the chemoresistance in CRC patients. | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |
| 10 | In conclusion, CEA-specific aptamer improved 5-FU sensitivity in chemoresistant colon cancer cells in vitro and in vivo, and thus represents a novel 5-FU adjuvant to overcome the chemoresistance in CRC patients. | Fluorouracil | CEA cell adhesion molecule 3 | Homo sapiens |