Pub. Date : 2019 Apr
PMID : 31020875
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxalomalate suppresses metastatic melanoma through IDH-targeted stress response to ROS. | Reactive Oxygen Species | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Oxalomalate (OMA) is a competitive inhibitor of NADP+-dependent isocitrate dehydrogenase (IDH), which plays an important role in cellular signalling pathways regulated by reactive oxygen species (ROS). | Reactive Oxygen Species | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | Oxalomalate (OMA) is a competitive inhibitor of NADP+-dependent isocitrate dehydrogenase (IDH), which plays an important role in cellular signalling pathways regulated by reactive oxygen species (ROS). | Reactive Oxygen Species | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 4 | These results provide evidence that OMA targeting of the stress response to ROS by IDH inhibition is a promising therapy for the treatment of metastatic melanoma. | Reactive Oxygen Species | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |