Pub. Date : 2019 Aug
PMID : 31018701
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress-induced apoptosis. | Curcumin | tumor protein p53 | Homo sapiens |
| 2 | Interestingly, at early times of exposure to a proapoptotic dose of curcumin (15 muM), we observed nuclear accumulation of Nrf2 and the expression of Nrf2 target genes, whereas at late exposure times we found a reduction of total and nuclear protein levels of Nrf2 as well as downregulation of Nrf2 target genes in the absence of p53 activation. | Curcumin | tumor protein p53 | Homo sapiens |