Title : pNNS-Conjugated Chitosan Mediated IGF-1 and miR-140 Overexpression in Articular Chondrocytes Improves Cartilage Repair.

Pub. Date : 2019

PMID : 31016187






1 Functional Relationships(s)
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1 In vivo, the exogenous genes enhanced COL2A1, ACAN, and TIMP-1 expression in cartilage and reduced cartilage Mankin score and the contents of NO, IL-1beta, TNF-alpha, and GAG contents in synovial fluid of rabbits, MMP-13, ADAMTS-5, COL1A2, and COL10A1 levels in cartilage. Glycosaminoglycans aggrecan core protein Oryctolagus cuniculus