Pub. Date : 2019 Jun
PMID : 31006824
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Multispecies study: low-dose tributyltin impairs ovarian theca cell cholesterol homeostasis through the RXR pathway in five mammalian species including humans. | tributyltin | retinoid X receptor alpha | Homo sapiens |
| 2 | RXR antagonist and RXRalpha knockdown demonstrates that TBT"s effect is partially through RXR. | tributyltin | retinoid X receptor alpha | Homo sapiens |
| 3 | RXR antagonist and RXRalpha knockdown demonstrates that TBT"s effect is partially through RXR. | tributyltin | retinoid X receptor alpha | Homo sapiens |
| 4 | RXR antagonist and RXRalpha knockdown demonstrates that TBT"s effect is partially through RXR. | tributyltin | retinoid X receptor alpha | Homo sapiens |
| 5 | TBT, at an environmentally relevant dose, stimulates theca cell cholesterol extracellular efflux via the RXR pathway, triggers a compensatory upregulation of StAR that regulates cholesterol transfer into the mitochondria and SREBF1 for de novo cholesterol synthesis. | tributyltin | retinoid X receptor alpha | Homo sapiens |