Title : Induction of the fibrinogen receptor on human platelets by intracellular mediators.

Pub. Date : 1987 Jan 25

PMID : 3100533






6 Functional Relationships(s)
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1 Indeed, we found that the G protein inhibitor guanyl-5"-yl thiophosphate (GDP beta S) inhibited PAC1 binding caused by a thromboxane A2 analog (U46619), IP3, and Ca2+, but had no effect on diacylglycerol or phorbol ester-induced PAC1 binding. guanosine 5'-O-(2-thiodiphosphate) dual specificity phosphatase 2 Homo sapiens
2 Indeed, we found that the G protein inhibitor guanyl-5"-yl thiophosphate (GDP beta S) inhibited PAC1 binding caused by a thromboxane A2 analog (U46619), IP3, and Ca2+, but had no effect on diacylglycerol or phorbol ester-induced PAC1 binding. guanosine 5'-O-(2-thiodiphosphate) dual specificity phosphatase 2 Homo sapiens
3 Indeed, we found that the G protein inhibitor guanyl-5"-yl thiophosphate (GDP beta S) inhibited PAC1 binding caused by a thromboxane A2 analog (U46619), IP3, and Ca2+, but had no effect on diacylglycerol or phorbol ester-induced PAC1 binding. guanosine 5'-O-(2-thiodiphosphate) dual specificity phosphatase 2 Homo sapiens
4 Indeed, we found that the G protein inhibitor guanyl-5"-yl thiophosphate (GDP beta S) inhibited PAC1 binding caused by a thromboxane A2 analog (U46619), IP3, and Ca2+, but had no effect on diacylglycerol or phorbol ester-induced PAC1 binding. guanosine 5'-O-(2-thiodiphosphate) dual specificity phosphatase 2 Homo sapiens
5 Thrombin-induced PAC1 binding and phosphoinositide hydrolysis were also inhibited by GDP beta S and by pertussis toxin. guanosine 5'-O-(2-thiodiphosphate) dual specificity phosphatase 2 Homo sapiens
6 Increasing the thrombin concentration overcame the inhibition of PAC1 binding caused by GDP beta S but did not overcome the inhibition of phosphoinositide hydrolysis. guanosine 5'-O-(2-thiodiphosphate) dual specificity phosphatase 2 Homo sapiens