Title : Time-restricted release of multiple neurotrophic factors promotes axonal regeneration and functional recovery after peripheral nerve injury.

Pub. Date : 2019 Jul

PMID : 30995417






2 Functional Relationships(s)
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1 In this study, we utilized the tetracycline-regulatable Tet-On 3G system to control the expression of c-Jun, which is a common regulator of multiple NTFs in Schwann cells (SCs). tetramethylenedisulfotetramine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 In vitro, Tet-On/c-Jun-modified SCs showed a tightly controllable secretion of multiple NTFs, including glial cell line-derived NTF, nerve growth factor, brain-derived NTF, and artemin, by the addition or removal of doxycycline (Dox). tetramethylenedisulfotetramine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens