Pub. Date : 2019 Dec 31
PMID : 30994173
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanistically, MDC-1112 inhibited STAT3 phosphorylation at the serine 727 residue, but not at tyrosine 705, in vitro and in vivo. | Serine | signal transducer and activator of transcription 3 | Mus musculus |
| 2 | In conclusion, MDC-1112 displays strong efficacy in preclinical models of GBM, with the serine 727 residue of STAT3 being its key molecular target. | Serine | signal transducer and activator of transcription 3 | Mus musculus |
| 3 | The novel agent MDC-1112 is an effective anticancer agent in multiple animal models of glioblastoma, and its mechanism of action involves the inhibition of STAT3 phosphorylation, primarily at its Serine 727 residue. | Serine | signal transducer and activator of transcription 3 | Mus musculus |