Title : Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET.

Pub. Date : 1987 Jan 23

PMID : 3099392






3 Functional Relationships(s)
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1 The anatomical distribution of 11C paralleled the distribution of MAO A and MAO B in human brain in autopsy material. Carbon-11 monoamine oxidase B Homo sapiens
2 A comparison of the brain uptake and retention of the 11C-labeled inactive (D-) and active (L-) enantiomers of deprenyl showed rapid clearance of the inactive enantiomer and retention of the active enantiomer within MAO B-rich brain structures, in agreement with the known stereoselectivity of MAO B for L-deprenyl. Carbon-11 monoamine oxidase B Homo sapiens
3 A comparison of the brain uptake and retention of the 11C-labeled inactive (D-) and active (L-) enantiomers of deprenyl showed rapid clearance of the inactive enantiomer and retention of the active enantiomer within MAO B-rich brain structures, in agreement with the known stereoselectivity of MAO B for L-deprenyl. Carbon-11 monoamine oxidase B Homo sapiens