Title : Rifampin Induces Expression of P-glycoprotein on the THP1 Cell-Derived Macrophages, Causing Decrease Intramacrophage Concentration of Prothionamide.

Pub. Date : 2019 Sep

PMID : 30991038






2 Functional Relationships(s)
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1 RIF-treated THP1 macrophages also exhibited strong efflux of P-gp substrate, resulting in a reduced intracellular concentration of rhodamine-123 and prothionamide (p < 0.01 and 0.05, respectively). Rhodamine 123 phosphoglycolate phosphatase Homo sapiens
2 By contrast, the P-gp inhibitor cyclosporine A significantly increased intracellular concentration of rhodamine-123 and prothionamide (p < 0.001 and 0.05, respectively). Rhodamine 123 phosphoglycolate phosphatase Homo sapiens