Pub. Date : 2019 Apr 3
PMID : 30987231
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Serial Femtosecond X-Ray Diffraction of HIV-1 Gag MA-IP6 Microcrystals at Ambient Temperature. | Phytic Acid | Pr55(Gag) | Human immunodeficiency virus 1 |
| 2 | Two different microcrystal forms of the MA-IP6 complex both diffracted to beyond 3.5 A resolution, demonstrating the feasibility of using SFX to study the complexes of MA domain of HIV-1 Gag polyprotein with IP6 at near-physiological temperatures. | Phytic Acid | Pr55(Gag) | Human immunodeficiency virus 1 |
| 3 | Two different microcrystal forms of the MA-IP6 complex both diffracted to beyond 3.5 A resolution, demonstrating the feasibility of using SFX to study the complexes of MA domain of HIV-1 Gag polyprotein with IP6 at near-physiological temperatures. | Phytic Acid | Pr55(Gag) | Human immunodeficiency virus 1 |
| 4 | Further optimization of the experimental and data analysis procedures will lead to better understanding of the MA domain of HIV-1 Gag and IP6 interaction at high resolution and will provide basis for optimization of the lead compounds for efficient inhibition of the Gag protein recruitment to the plasma membrane prior to virion formation. | Phytic Acid | Pr55(Gag) | Human immunodeficiency virus 1 |