Title : Nicotinic Agonist Inhibits Cardiomyocyte Apoptosis in CVB3-Induced Myocarditis via α3β4-nAChR/PI3K/Akt-Dependent Survivin Upregulation.

Pub. Date : 2019

PMID : 30984342






2 Functional Relationships(s)
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1 The results of the TUNEL assay and western blot experiments showed that the block of alpha3beta4-nAChRs abrogated nicotine-mediated protection of NRC from CVB3-induced apoptosis, and this effect displayed a substantial correlation with the protein expressions of pAkt, survivin, and Cleaved Caspase-3. Nicotine baculoviral IAP repeat-containing 5 Mus musculus
2 As a result, nicotine-mediated induction of pAkt and survivin was abolished by LY294002; meanwhile, apoptotic NRC were increased accompanied by an increase of Cleaved Caspase-3 expression. Nicotine baculoviral IAP repeat-containing 5 Mus musculus