Pub. Date : 2019 May 17
PMID : 30978004
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our optimized probe, HaloPROTAC-E, a chloroalkane conjugate of high-affinity VHL binder VH298, induced reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM. | HaloPROTAC-E | phosphatidylinositol 3-kinase catalytic subunit type 3 | Homo sapiens |
| 2 | HaloPROTAC-E more potently induced greater steady state degradation of Halo tagged endogenous VPS34 than the previously reported HaloPROTAC3 compound. | HaloPROTAC-E | phosphatidylinositol 3-kinase catalytic subunit type 3 | Homo sapiens |