Title : Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader.

Pub. Date : 2019 May 17

PMID : 30978004






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 HaloPROTAC-E induced rapid (~50% degradation after 30 min) and complete ( Dmax of ~95% at 48 h) depletion of Halo-tagged SGK3, blocking downstream phosphorylation of the SGK3 substrate NDRG1. HaloPROTAC-E N-myc downstream regulated 1 Homo sapiens