Pub. Date : 2019 Aug
PMID : 30973652
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methadone exposure was reduced when it was coadministered with CYP2B6 inducers. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | In conclusion, CYP2B6 plays a prominent role in methadone metabolism, although methadone exposure is not sensitive to CYP3A perturbation. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | In designing methadone DDI studies, (1) measuring R- and S-methadone is more informative than measuring total methadone, and (2) CYP2B6 genotyping of subjects enrolled in methadone DDI studies should be considered. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |