Title : Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.

Pub. Date : 2019 Jun 1

PMID : 30962087






1 Functional Relationships(s)
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1 A series of DNA gyrase inhibitors were designed based on the X-ray structure of a parent thiophene scaffold with the objective to improve biochemical and whole-cell antibacterial activity, while reducing cardiac ion channel activity. Thiophenes DNA topoisomerase II alpha Homo sapiens