Title : R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features.

Pub. Date : 2019 Jul

PMID : 30957963






1 Functional Relationships(s)
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1 These changes are consistent with the spectroscopic and kinetic results, indicating that the variant, as compared with the wild-type OAT, shows (a) an increased Km value for l-ornithine (l-Orn), (b) an altered pyridoxal 5"-phosphate binding mode and affinity and (c) an increased thermostability. Pyridoxal Phosphate ornithine aminotransferase, mitochondrial Cricetulus griseus