Title : Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling.

Pub. Date : 2019 Aug

PMID : 30957236






1 Functional Relationships(s)
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1 Additionally, pretreatment with noneffective doses of an opioid receptor antagonist (naltrexone) and NMDA receptor antagonists (ketamine and MK-801) inhibited methadone"s proconvulsive activity in the acute phase, while l-NAME (a nonspecific nitric oxide synthase (NOS) inhibitor) did not affect that activity. Dizocilpine Maleate nitric oxide synthase 1, neuronal Mus musculus