Title : Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound.

Pub. Date : 2019 Jun 1

PMID : 30952593






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In recent efforts, several C20" urea vinblastine analogues were discovered that displayed remarkable potency against vinblastine-sensitive tumor cell lines (IC50 50-75 pM), being roughly 100-fold more potent than vinblastine, and that exhibited decreased susceptibility to Pgp efflux-derived resistance in a vinblastine-resistant cell line. Vinblastine phosphoglycolate phosphatase Homo sapiens