Title : Simultaneously down-regulation of multiplex branch pathways using CRISPRi and fermentation optimization for enhancing β-amyrin production in Saccharomyces cerevisiae.

Pub. Date : 2019 Jun

PMID : 30949594






2 Functional Relationships(s)
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1 In this study, we focused on two branches of beta-amyrin synthetics pathway that consume beta-amyrin precursors (2,3-oxidosqualene and cytosolic acetyl-CoA) and regulated related genes (ADH1, ADH4, ADH5, ADH6, CIT2, MLS2 and ERG7). beta-amyrin alcohol dehydrogenase ADH4 Saccharomyces cerevisiae S288C
2 In this study, we focused on two branches of beta-amyrin synthetics pathway that consume beta-amyrin precursors (2,3-oxidosqualene and cytosolic acetyl-CoA) and regulated related genes (ADH1, ADH4, ADH5, ADH6, CIT2, MLS2 and ERG7). beta-amyrin alcohol dehydrogenase ADH4 Saccharomyces cerevisiae S288C