Title : Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-α Production in Macrophages and Directly Inhibiting Osteoclast Formation.

Pub. Date : 2019

PMID : 30949128






5 Functional Relationships(s)
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1 Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-alpha Production in Macrophages and Directly Inhibiting Osteoclast Formation. Docosahexaenoic Acids free fatty acid receptor 4 Mus musculus
2 DHA exerts potent anti-inflammatory effects through G protein-coupled receptor 120 (GPR120), which is a functional receptor for n-3 fatty acids. Docosahexaenoic Acids free fatty acid receptor 4 Mus musculus
3 DHA exerts potent anti-inflammatory effects through G protein-coupled receptor 120 (GPR120), which is a functional receptor for n-3 fatty acids. Docosahexaenoic Acids free fatty acid receptor 4 Mus musculus
4 Finally, the inhibitory effects of DHA on osteoclast formation in vitro were not observed by using osteoclast precursors from GPR120-deficient mice, and inhibition of LPS-induced osteoclast formation and bone resorption by DHA in vivo was not observed in GPR120-deficient mice. Docosahexaenoic Acids free fatty acid receptor 4 Mus musculus
5 These results suggest that DHA inhibits LPS-induced osteoclast formation and bone resorption in vivo via GPR120 by inhibiting LPS-induced TNF-alpha production in macrophages along with direct inhibition of osteoclast formation. Docosahexaenoic Acids free fatty acid receptor 4 Mus musculus