Pub. Date : 2019 Apr 3
PMID : 30944389
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A mechanistic study revealed that GlcN inhibited the expression of NLRP3 and IL-1beta precursor by reducing reactive oxygen species generation and NF-kappaB activation in lipopolysaccharide-activated macrophages. | Glucosamine | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | GlcN also suppressed mitochondrial reactive oxygen species generation and mitochondrial integrity loss in NLRP3-activated macrophages. | Glucosamine | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Additionally, GlcN disrupted NLRP3 inflammasome assembly by inhibiting NLRP3 binding to PKR, NEK7 and ASC. | Glucosamine | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Additionally, GlcN disrupted NLRP3 inflammasome assembly by inhibiting NLRP3 binding to PKR, NEK7 and ASC. | Glucosamine | NLR family pyrin domain containing 3 | Homo sapiens |