Title : Computational Tools Unravel Putative Sterol Binding Sites in the Lysosomal NPC1 Protein.

Pub. Date : 2019 May 28

PMID : 30942586






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 NPC1 is believed to act in tandem with NPC2, transferring cholesterol and other sterols out of the LE/Lys compartments. Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens
2 Mutations in either NPC1 or NPC2 can lead to an accumulation of cholesterol and lipids in the LE/Lys, the primary phenotype of the NPC disease, but approximately 95% of identified disease-causing mutations have been mapped to the membrane-bound NPC1 protein. Cholesterol NPC intracellular cholesterol transporter 1 Homo sapiens