Pub. Date : 2019 May 28
PMID : 30942586
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | NPC1 is believed to act in tandem with NPC2, transferring cholesterol and other sterols out of the LE/Lys compartments. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
2 | Mutations in either NPC1 or NPC2 can lead to an accumulation of cholesterol and lipids in the LE/Lys, the primary phenotype of the NPC disease, but approximately 95% of identified disease-causing mutations have been mapped to the membrane-bound NPC1 protein. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |