Title : Targeting CD38 Enhances the Antileukemic Activity of Ibrutinib in Chronic Lymphocytic Leukemia.

Pub. Date : 2019 Jul 1

PMID : 30940652






1 Functional Relationships(s)
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1 For the first time, we demonstrated the influence of CD38 on BCR signaling where interference of CD38 downregulated Syk, BTK, PLCgamma2, ERK1/2, and AKT; effects that were further enhanced by addition of ibrutinib. ibrutinib phospholipase C gamma 2 Homo sapiens