Title : The synthesis of 4,6-diaryl-2-pyridones and their bioactivation in CYP1 expressing breast cancer cells.

Pub. Date : 2019 Jun 1

PMID : 30935796






1 Functional Relationships(s)
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1 As part of a programme to develop anticancer prodrugs which are activated by cytochrome P450 (CYP)1B1, a library of 4,6-diaryl-2-pyridones was synthesised in yields of 6-60% from the corresponding chalcones. Chalcones cytochrome P450 family 1 subfamily B member 1 Homo sapiens