Title : Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes.

Pub. Date : 2019 Mar 31

PMID : 30935113






2 Functional Relationships(s)
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1 The purpose of these studies was to define the role of ACSL-5 in mitochondrial fatty acid metabolism and the potential effects on insulin action in human skeletal muscle cells (HSKMC). Fatty Acids acyl-CoA synthetase long chain family member 5 Homo sapiens
2 We concluded that ACSL-5 in human skeletal muscle functions to increase mitochondrial fatty acid oxidation, but contrary to conventional wisdom, is associated with increased free radical production and reduced insulin signaling. Fatty Acids acyl-CoA synthetase long chain family member 5 Homo sapiens