Title : Synthesis and Evaluation of Oligomeric Thioether-Linked Carbacyclic β-(1→3)-Glucan Mimetics.

Pub. Date : 2019 May 3

PMID : 30933504






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1 Synthesis and Evaluation of Oligomeric Thioether-Linked Carbacyclic beta-(1 3)-Glucan Mimetics. Sulfides immunoglobulin kappa variable 2D-18 (pseudogene) Homo sapiens
2 Extrapolating from lessons learnt with previous low-molecular-weight beta-(1 3)-glucan mimetics, we designed a series of minimal 2,4-dideoxy-thioether-linked carbacyclic beta-(1 3)-glucan mimetics and synthesized di-, tri-, and tetramers in an enantiomerically pure form by an iterative sequence based on a simple building block readily available from commercial ( S)-(-)-3-cyclohexenecarboxylic acid. Sulfides immunoglobulin kappa variable 2D-18 (pseudogene) Homo sapiens
3 Extrapolating from lessons learnt with previous low-molecular-weight beta-(1 3)-glucan mimetics, we designed a series of minimal 2,4-dideoxy-thioether-linked carbacyclic beta-(1 3)-glucan mimetics and synthesized di-, tri-, and tetramers in an enantiomerically pure form by an iterative sequence based on a simple building block readily available from commercial ( S)-(-)-3-cyclohexenecarboxylic acid. Sulfides immunoglobulin kappa variable 2D-18 (pseudogene) Homo sapiens