Title : Point mutations in the PDX1 transactivation domain impair human β-cell development and function.

Pub. Date : 2019 Jun

PMID : 30930126






3 Functional Relationships(s)
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1 Additionally, both PDX1P33T/+ and PDX1P33T/P33T mutations in PPs reduced the expression of PDX1-bound genes including the long-noncoding RNA, MEG3 and the imprinted gene NNAT, both involved in insulin synthesis and secretion. pps pancreatic and duodenal homeobox 1 Homo sapiens
2 Additionally, both PDX1P33T/+ and PDX1P33T/P33T mutations in PPs reduced the expression of PDX1-bound genes including the long-noncoding RNA, MEG3 and the imprinted gene NNAT, both involved in insulin synthesis and secretion. pps pancreatic and duodenal homeobox 1 Homo sapiens
3 Additionally, both PDX1P33T/+ and PDX1P33T/P33T mutations in PPs reduced the expression of PDX1-bound genes including the long-noncoding RNA, MEG3 and the imprinted gene NNAT, both involved in insulin synthesis and secretion. pps pancreatic and duodenal homeobox 1 Homo sapiens