Pub. Date : 2019 Mar
PMID : 30915775
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) reduced the behavioral abnormalities caused by ceramide accumulation, downregulated CONCLUSIONS: The experimental results suggest that ceramide reduces EAAT-2 expression through the NF-kappaB/TNF-alpha pathway and causes neuronal excitotoxicity in the pathogenesis of schizophrenia, leading to neuronal damage. | Ceramides | tumor necrosis factor | Homo sapiens |