Title : Asthmatic Augmentation of Airway Vagal Activity Involves Decreased Central Expression and Activity of CD73 in Rats.

Pub. Date : 2019 Jun 19

PMID : 30913879






2 Functional Relationships(s)
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1 Here we report that in an asthma model of male Sprague-Dawley rats, the expression and activity of ecto-5"-nucleotidase (CD73) were decreased in airway vagal centers, ATP concentration in cerebral spinal fluid was increased, and the inhibitory and excitatory airway vagal responses to intracisternally injected ATP (5 mumol) and CD73 inhibitor AMPCP (5 mumol), respectively, were attenuated. alpha,beta-methyleneadenosine 5'-diphosphate 5' nucleotidase, ecto Rattus norvegicus
2 Here we report that in an asthma model of male Sprague-Dawley rats, the expression and activity of ecto-5"-nucleotidase (CD73) were decreased in airway vagal centers, ATP concentration in cerebral spinal fluid was increased, and the inhibitory and excitatory airway vagal responses to intracisternally injected ATP (5 mumol) and CD73 inhibitor AMPCP (5 mumol), respectively, were attenuated. alpha,beta-methyleneadenosine 5'-diphosphate 5' nucleotidase, ecto Rattus norvegicus