Pub. Date : 2019 Jul
PMID : 30907440
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Relevance of CYP2B6 and CYP2D6 genotypes to methadone pharmacokinetics and response in the OPAL study. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | AIMS: Our study aimed to evaluate the impacts of the cytochrome P450 (CYP) 2B6-G516T and CYP2D6 genetic polymorphisms on pharmacokinetic and clinical parameters in patients receiving methadone maintenance treatment. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | RESULTS: When comparing the three CYP2B6 genotype groups, the methadone (R)- and (S)-methadone enantiomer concentrations/doses (concentrations relative to doses) were different (P = .029, P = .0019). | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | RESULTS: When comparing the three CYP2B6 genotype groups, the methadone (R)- and (S)-methadone enantiomer concentrations/doses (concentrations relative to doses) were different (P = .029, P = .0019). | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | CONCLUSION: The genotyping of CYP2B6 G516T could be an interesting tool to explore methadone intervariability. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |