Pub. Date : 2019 May 1
PMID : 30898641
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Herein, we utilize a surfactant-like chemotherapeutic agent, mitoxantrone (MTX), as a nanocarrier to deliver a photosensitizer pyropheophorbide a (PPa) for antitumor therapy. | Mitoxantrone | preproenkephalin | Mus musculus |
| 2 | Herein, we utilize a surfactant-like chemotherapeutic agent, mitoxantrone (MTX), as a nanocarrier to deliver a photosensitizer pyropheophorbide a (PPa) for antitumor therapy. | Mitoxantrone | preproenkephalin | Mus musculus |
| 3 | MTX consists of aromatic rings (hydrophobic part) and two amino-groups and two hydroxyl-groups (hydrophilic part) with planar structure, which could interact with PPa via pi-pi stacking, hydrophobic interactions, intermolecular hydrogen bonding and electrostatic interactions. | Mitoxantrone | preproenkephalin | Mus musculus |
| 4 | This system (PPa@MTX) spontaneously forms near-spherical nanostructures (~150 nm), has a high loading capacity for PPa (56.5%) and exhibits a pH-responsive drug release manner in vitro. | Mitoxantrone | preproenkephalin | Mus musculus |
| 5 | This system (PPa@MTX) spontaneously forms near-spherical nanostructures (~150 nm), has a high loading capacity for PPa (56.5%) and exhibits a pH-responsive drug release manner in vitro. | Mitoxantrone | preproenkephalin | Mus musculus |
| 6 | In vivo antitumor efficacy evaluations show that the pegylated PPa@MTX nanosystem has increased accumulation in tumor tissues and enhanced antitumor efficacy in female BALB/c mice bearing murine mammary carcinoma (4T1) tumor cells, compared to free PPa. | Mitoxantrone | preproenkephalin | Mus musculus |
| 7 | In vivo antitumor efficacy evaluations show that the pegylated PPa@MTX nanosystem has increased accumulation in tumor tissues and enhanced antitumor efficacy in female BALB/c mice bearing murine mammary carcinoma (4T1) tumor cells, compared to free PPa. | Mitoxantrone | preproenkephalin | Mus musculus |