Pub. Date : 2019 May
PMID : 30896855
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR. | obeticholic acid | scavenger receptor class B member 1 | Homo sapiens |
| 2 | Our previous study demonstrated that the activation of FXR by obeticholic acid (OCA) lowered plasma HDL-cholesterol levels and increased the hepatic mRNA and protein expression levels of SR-BI in hypercholesterolemic hamsters, but not in normolipidemic hamsters, suggesting that dietary cholesterol may be involved in the OCA-induced transcription of SR-BI. | obeticholic acid | scavenger receptor class B member 1 | Homo sapiens |
| 3 | Our previous study demonstrated that the activation of FXR by obeticholic acid (OCA) lowered plasma HDL-cholesterol levels and increased the hepatic mRNA and protein expression levels of SR-BI in hypercholesterolemic hamsters, but not in normolipidemic hamsters, suggesting that dietary cholesterol may be involved in the OCA-induced transcription of SR-BI. | obeticholic acid | scavenger receptor class B member 1 | Homo sapiens |
| 4 | Our previous study demonstrated that the activation of FXR by obeticholic acid (OCA) lowered plasma HDL-cholesterol levels and increased the hepatic mRNA and protein expression levels of SR-BI in hypercholesterolemic hamsters, but not in normolipidemic hamsters, suggesting that dietary cholesterol may be involved in the OCA-induced transcription of SR-BI. | obeticholic acid | scavenger receptor class B member 1 | Homo sapiens |
| 5 | Our previous study demonstrated that the activation of FXR by obeticholic acid (OCA) lowered plasma HDL-cholesterol levels and increased the hepatic mRNA and protein expression levels of SR-BI in hypercholesterolemic hamsters, but not in normolipidemic hamsters, suggesting that dietary cholesterol may be involved in the OCA-induced transcription of SR-BI. | obeticholic acid | scavenger receptor class B member 1 | Homo sapiens |