Title : Mechanism of Rapid Nuclear Factor-E2-Related Factor 2 (Nrf2) Activation via Membrane-Associated Estrogen Receptors: Roles of NADPH Oxidase 1, Neutral Sphingomyelinase 2 and Epidermal Growth Factor Receptor (EGFR).

Pub. Date : 2019 Mar 18

PMID : 30889865






1 Functional Relationships(s)
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1 We propose a novel hypothesis that ER-alpha36-GPER signaling initially induces rapid and temporal activation of NADPH oxidase 1 to generate superoxide, which subsequently activates redox-sensitive neutral sphingomyelinase 2 generating the lipid signaling mediator ceramide. Superoxides NADPH oxidase 1 Homo sapiens