Title : A Phase I Open-Label Study to Evaluate the Effects of Rifampin on the Pharmacokinetics of Olanzapine and Samidorphan Administered in Combination in Healthy Human Subjects.

Pub. Date : 2019 May

PMID : 30888624






1 Functional Relationships(s)
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1 The primary metabolic pathways for olanzapine are direct glucuronidation via uridine 5"-diphospho-glucuronosyltransferase (UGT)1A4 and cytochrome P450 (CYP)-mediated oxidation, mainly by CYP1A2. Olanzapine UDP glucuronosyltransferase family 1 member A4 Homo sapiens