Pub. Date : 2019 Jun
PMID : 30885990
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived PC (BMPC) dysfunction through augmenting the activity of an important endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), resulting in improved diabetic wound healing. | Pyruvaldehyde | glyoxalase 1 | Mus musculus |
| 2 | We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived PC (BMPC) dysfunction through augmenting the activity of an important endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), resulting in improved diabetic wound healing. | Pyruvaldehyde | glyoxalase 1 | Mus musculus |
| 3 | MGO at the concentration of 10 micromol/L induced immediate and severe BMPC dysfunction, including impaired network formation, migration, and proliferation and increased apoptosis, which were rescued by adenovirus-mediated GLO1 overexpression. | Pyruvaldehyde | glyoxalase 1 | Mus musculus |
| 4 | In conclusion, our data suggest that GLO1 rescues BMPC dysfunction and facilitates wound healing in diabetic animals, at least partly through preventing MGO-induced impairment of IRE1alpha expression and activity. | Pyruvaldehyde | glyoxalase 1 | Mus musculus |