Pub. Date : 2019 Apr
PMID : 30881498
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol induces p53 in colorectal cancer through SET7/9. | Resveratrol | tumor protein p53 | Homo sapiens |
| 2 | Additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including Bcl2 associated X, apoptosis regulator and Bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. | Resveratrol | tumor protein p53 | Homo sapiens |
| 3 | Additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including Bcl2 associated X, apoptosis regulator and Bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. | Resveratrol | tumor protein p53 | Homo sapiens |
| 4 | Additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including Bcl2 associated X, apoptosis regulator and Bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. | Resveratrol | tumor protein p53 | Homo sapiens |
| 5 | Additionally, resveratrol enhanced the expression of tumour protein p53 (p53) and p53 target genes, including Bcl2 associated X, apoptosis regulator and Bcl2 binding component 3 that have a pivotal role in p53-dependent apoptosis. | Resveratrol | tumor protein p53 | Homo sapiens |
| 6 | Furthermore, treating cells with resveratrol upregulated SET domain containing lysine methyltransferase 7/9 (SET7/9) expression, which positively regulates p53 through its mono-methylation at lysine 372, compared with untreated cells. | Resveratrol | tumor protein p53 | Homo sapiens |
| 7 | However, the genetic knockdown of SET7/9 by short hairpin RNA attenuated the resveratrol-driven overexpression of p53, cleaved caspase-3 and PARP. | Resveratrol | tumor protein p53 | Homo sapiens |
| 8 | Collectively, these results reveal the molecular mechanisms by which resveratrol induces p53 stability in colon cancer that results in the activation of p53-mediated apoptosis. | Resveratrol | tumor protein p53 | Homo sapiens |
| 9 | Collectively, these results reveal the molecular mechanisms by which resveratrol induces p53 stability in colon cancer that results in the activation of p53-mediated apoptosis. | Resveratrol | tumor protein p53 | Homo sapiens |