Title : Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinson's disease.

Pub. Date : 2019 Apr 15

PMID : 30880023






3 Functional Relationships(s)
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1 Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-kappaB signaling pathway in a mouse model of Parkinson"s disease. rosmarinic acid high mobility group box 1 Mus musculus
2 Furthermore, RA treatment downregulated the expression levels of HMGB1, TLR4 and Myd88 and inhibited NF-kappaB nuclear expression both in PD animal and cell models. rosmarinic acid high mobility group box 1 Mus musculus
3 These findings indicated that RA could attenuate inflammatory responses through suppressing HMGB1/TLR4/NF-kappaB signaling pathway, which may contribute to its anti-PD activity. rosmarinic acid high mobility group box 1 Mus musculus