Pub. Date : 2019 Mar 14
PMID : 30875717
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Effect of Green and Black Tea Polyphenols on BRCA2 Deficient Chinese Hamster Cells by Synthetic Lethality through PARP Inhibition. | Polyphenols | LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein | Cricetulus griseus |
| 2 | The observed cytotoxicity of these polyphenols to BRCA2 deficient cells is believed to be a result of PARP inhibition induced synthetic lethality. | Polyphenols | LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein | Cricetulus griseus |
| 3 | Polyphenol treatment induced more micronuclei formation in BRCA2 deficient cells and rad51D deficient cells when compared against the respective wild type cells. | Polyphenols | LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein | Cricetulus griseus |
| 4 | In conclusion, tea polyphenols, epigallocatechin gallate, and theaflavin may present selective cytotoxicity to BRCA2 deficient cells through synthetic lethality induced by PARP inhibition. | Polyphenols | LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein | Cricetulus griseus |