Pub. Date : 2019 Jun
PMID : 30873627
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A population pharmacokinetic model of vancomycin for dose individualization based on serum cystatin C as a marker of renal function. | Vancomycin | cystatin C | Homo sapiens |
| 2 | OBJECTIVES: This study aimed to establish a vancomycin population pharmacokinetics (PPK) model based on serum cystatin C and to optimize dosing for achieving targeted steady-state trough concentrations (Css ) of 10-15 and 15-20 mg/l. | Vancomycin | cystatin C | Homo sapiens |
| 3 | A vancomycin PPK model was built with glomerular filtration rate (GFR) as a renal covariate estimated by cystatin C. | Vancomycin | cystatin C | Homo sapiens |
| 4 | CONCLUSIONS: A vancomycin PPK model with cystatin C as the renal marker has good stability and predictability. | Vancomycin | cystatin C | Homo sapiens |